Nearly four in 10 TIA and minor stroke patients may experience cognitive problems, according to researchers evaluating 140 consecutive patients (average age 67) admitted to the Urgent TIA Clinic at the London Health Sciences Centre in London, Ontario, according to a study presented at the American Stroke Association's International Stroke Conference 2010

Researchers evaluated 140 patients (average age 67) admitted to the Urgent TIA Clinic at the London Health Sciences Centre in London, Ontario. Within a week of symptom onset, the researchers used a short, easily administered battery of tests that can detect deficits in so-called "executive functions," including speed of mental processing, abstraction and reasoning ability. They found that these functions - higher-level cognitive skills that control and coordinate other mental abilities and behaviors - were impaired in almost 40 percent of the TIA and minor stroke patients.

Researchers have known that TIAs and minor strokes can subtly change mental abilities, a condition known as vascular cognitive impairment. But little has been known about how common impairment was in these patients.

"Transient ischemic attacks and minor strokes are not just a warning of future stroke. They are an indication that the process of brain injury may have begun," said Michael Harnadek, Ph.D., the study's lead author and a neuropsychologist with the London Health Sciences Centre.

Researchers also administered the most commonly used test for mental functioning, the Mini Mental Status Exam, which is designed to identify patients with Alzheimer's dementia. They found that test couldn't detect the cognitive problems in minor stroke and TIA patients. Harnadek said this indicates while cognitive impairment is common in patients who have experienced TIAs and minor strokes, it can be missed if doctors rely only on measures designed to test for Alzheimer's dementia.

"Using measures that specifically test executive functioning, screening for cognitive impairment can be done quickly and easily," he said.

Ischemic events - caused by a blockage in a blood vessel in or leading to the brain - account for about 85 percent of all strokes. About one-third of people who have a TIA, also known as a "warning stroke," have a stroke within a year, according to the American Stroke Association.

Among the patients in the study who experienced a TIA, symptoms went away within 24 hours, while for the minor stroke patients, physical or sensory symptoms persisted but didn't cause serious disability.

Sixty-one percent of the study subjects were women, but the researchers haven't yet determined whether rates of impairment varied between males and females. The study also didn't include enough patients to discern differences among racial or ethnic groups, Harnadek said.

The study should be replicated elsewhere to see whether rates of impairment are similar for the same type of patients, he said. Researchers should also try to learn whether patients' impairment interferes with their ability to understand and follow the treatment guidance their physician provides.

"Our research, and similar studies, underscores the need for the prevention of cerebrovascular disease, as well as early detection and treatment in those affected, to preserve cognitive health," Harnadek said.

Co-authors are: Richard Chan, M.D.; Cheryl Mayer, R.N., M.Sc.N.; and Vladimir Hachinski, M.D., D.Sc. Author disclosures are on the abstract.

Funding for the study was provided through the Canadian Stroke Network.