Adolescents with major depressive disorder appear to respond better to antidepressants combined with psychotherapy than either modality alone, according to an article in the October issue of the Archives of General Psychiatry.

The new findings come from a major clinical trial funded by the National Institutes of Health's National Institute of Mental Health. The long-term results of the Treatment for Adolescents with Depression Study (TADS) found that when adolescents received fluoxetine alone or in combination with cognitive behavioral therapy over the course of 36 weeks, they recovered faster than those who were receiving cognitive behavioral therapy alone.

However, taking fluoxetine alone appeared to pose some safety concerns for the teens. During treatment, those taking fluoxetine alone had higher rates of suicidal thinking (15 percent) than those in combination treatment (8 percent) and those in psychotherapy alone (6 percent), particularly in the early stages of treatment.

This result suggests that while treatment with fluoxetine may speed recovery, adding cognitive behavioral therapy provides additional safeguards for patients vulnerable to suicide, according to the researchers.

"Depression in teens is a serious illness that can and should be treated aggressively," said NIMH Director Thomas R. Insel, M.D. "TADS provides compelling evidence for families and clinicians that the most effective way to treat depression in teens is with a two-pronged approach. It reassures us that antidepressant medication combined with psychotherapy is an effective and safe way to help teens recover from this disabling illness."

Results at 36 weeks of treatment were consistent with those found at 12 weeks [link to http://www.nimh.nih.gov/science-news/2004/combination-treatment-most-effective-in-adolescents-with-depression.shtml] in the 439-person study, when researchers reported that combination treatment produced the greatest improvement in teenagers with major depression. At 18 weeks (results not previously reported), combination treatment still outpaced the other treatments with an 85 percent response rate, compared to 69 percent for fluoxetine alone and 65 percent for psychotherapy alone. By 36 weeks, the response rate to combination treatment still remained the highest (86 percent), while response rates to fluoxetine and CBT essentially caught up, at 81 percent each.

"In the combination approach, the two treatments complemented each other," said John March, M.D, MPH, of Duke University and lead author of the study. "The fluoxetine can help dissipate the physical symptoms of major depression relatively quickly, and cognitive behavioral therapy can help patients develop new skills to contend with difficult, negative emotions."

Because the trial sample included a mix of younger and older teens, both genders, substantial minority representation and variable socioeconomic status, the results can be applied broadly to the adolescent population.