The use of statins and other lipid-lowering agents by older adults does not reduce risk for Alzheimer’s disease or other types of dementia, according to an article in the July issue of Archives of Neurology.

Statins may reduce cardiovascular risk by inhibiting cholesterol synthesis or through anti-inflammatory effects, biological mechanisms that may play a role in development of dementia, particularly Alzheimer’s disease, according to background information in the article. Previous studies have suggested that statins may have a protective effect on the process of dementia, either preventing or delaying onset.

In the current research, Thomas D. Rea, MD, MPH, and his American colleagues assessed data on 2,798 participants 65 years or older in the Cardiovascular Health Study who underwent baseline magnetic resonance imaging and took a standardized mental test to determine they were free of dementia when enrolled in the study (between 1991 and 1994).

At baseline, information on health status, cognitive function and medication use, as well as laboratory assessments and diagnostic testing, was collected. Participants were followed annually to assess health status, medication use, and possible dementia. During a total of 15,030 person years of follow-up, 480 cases of dementia were diagnosed, including 245 cases of Alzheimer’s disease.

After controlling for other known or suspected risk factors, the researchers found that patients who had ever used statins had no reduction in risk for dementia from any cause (Alzheimer’s disease, mixed Alzheimer’s disease and vascular dementia or vascular dementia alone) compared with those who had never used statins.

“Several factors may explain why statin use was not associated with a lower risk of dementia,” the authors wrote. “Participants were on average 75 years of age, and statin use was assessed for a median of five years. Statin exposure may need to occur earlier in adulthood or for longer periods to prevent dementia, although analyses that stratified the duration of statin use did not suggest a duration-dependent association.”

“In this investigation, statin therapy was not associated with a lower risk of dementia,” the authors concluded. “Although statin use is an important treatment for cardiovascular disease, additional investigation is needed to determine whether and for whom statin use may affect dementia risk.”