New study suggests that long-term cognitive decline is not inevitable after certain coronary procedures
New research challenges previous findings
that patients undergoing elective coronary bypass grafting or valve
replacement experience long-term cognitive decline, according to an
article in the September issue of Neurology.
The German study compared the cognitive abilities
of 52 patients prior to coronary artery bypass grafting surgery
and five years afterward. None of the patients showed clinically
significant cognitive decline when defined as a decline of 1 standard
deviation or more in at least two of the seven-part Wilcoxon tests.
Other studies have reported late cognitive
decline after bypass surgery. However, none of these long-term follow-up
studies included a control group, as did the current study. Wolfgang
Mullges, M.D., lead author, said "No individual patient showed
a global decline at follow-up as compared to baseline. Seven patients
(13 percent) had worse results in one single test."
The researchers also compared follow-up data
with data obtained at discharge. In this comparison, only four patients
(8 percent) showed a standard deviation of more than 1 percent in
two of the tests. Sixteen patients (31 percent) had lower follow-up
test scores in only one of the tests, and 46 (88 percent) had better
results in at least one test.
The patients in this study may have had better
outcomes through general medical care and by reducing vascular risk
factors following surgery, said Mullges. "Many of the individuals
had stopped smoking, many were prescribed statins, and many took
steps to control their diabetes and hypertension," he noted.
One study limitation was a lack of data or
incomplete data from a portion of the 92 original members of the
patient group, and this may have introduced a bias toward a better
outcome.
Mullges said physicians other than cardiologists
should work with patients to provide care that reduces vascular
risk for myocardial infarction, stroke, and vascular dementia. "Treatment
of cardiac patients means more than surgery," he said.
The result could be a better quality of life
for the growing elderly population. Active risk reduction may be
even more strongly indicated for patients with preexistent cognitive
or emotional problems.
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