Parkinson's patients with dementia have up to a three-fold increase in mortality


Research indicates that the presence of dementia in patients with Parkinson's disease is associated with risk for death independently of severity of motor disease, according to a presentation at the 2002 Annual Meeting of the American Academy of Neurology.

"Previous studies had shown dementia to be associated with reduced survival among Parkinson's disease patients," said study author Karen Marder, M.D. "However we were unsure whether reduced survival was due to the fact that individuals with dementia were also the most severely affected in terms of the motor signs of Parkinson's disease."

The current study, which involved evaluation and follow-up of 180 patients, also revealed that patients who died during the four-year follow-up period were significantly older and had a higher Parkinson's severity at baseline than those who were still living. After adjustment for age, gender, education, and duration of disease, both presence of dementia and severity of disease were independently associated with increased risk of death.

The risk of mortality associated with incident dementia was between two- and three-fold. This risk was unchanged after adjusting for the development of hallucinations or depression.




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