Genetically determined differences in natural postmenopausal estrogen levels may explain known differences in breast cancer incidence among races and ethnic groups, according to an article in the October issue of Cancer Epidemiology, Biomarkers & Prevention.

Using data from the US Multiethnic Cohort Study, V. Wendy Setiawan, PhD, of the University f Southern California, and her colleagues determined that of the five primary ethnicities/races in the cohort, native Hawaiians have the highest risk of breast cancer?65 percent greater than Caucasians. They also had some of the highest levels of circulating estrogens.

“We had observed that some groups, such as native Hawaiians have higher breast cancer rates compared to white women. We knew hormones are a factor, so we decided to test them,” said Setiawan. “The research seems to support that idea.”
The researchers also found that Japanese-American women have comparatively high estrogen levels and the second highest breast cancer risk of the five groups.

“This is interesting because breast cancer rates have been increasing steadily in Japanese women who live in the United States, as well as in women who live in Japan,” Setiawan said. “We think it could be caused by lifestyle changes that impact age at first menstruation or other factors.”

Latinas had similar hormone profiles to whites, while women who had recently immigrated had slightly lower levels, but which were not statistically significant, the researchers found. However, Latinas’ risk of breast cancer is the lowest of the groups studied. One of the most interesting findings was that African-American women have a slightly lower post-menopausal breast cancer risk than whites, despite having comparatively higher post-menopausal hormone levels.

The researchers analyzed the hormone levels in 739 postmenopausal women in the cohort who were not on hormone replacement therapy. After adjusting hormone levels for age, body mass index, and other lifestyle factors, they compared levels to their ethnic/racial groups’ breast cancer incidences. The study is the largest analysis of hormone levels by ethnic group, and the first large study of native Hawaiians and Latinas.

“Clearly, more work is needed to identify factors that contribute to racial and ethnic differences in hormone levels,” Setiawan concluded.