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Purple grape juice inhibits breast cancer cell growth in rats and in cell cultures


Consumption of purple grape juice by female rats led to significant reductions in both mammary tumor mass and the number of tumors per animal, according to a study presented at the International Scientific Conference on Complementary, Alternative and Integrative Medical Research, cosponsored by Harvard Medical School. The researchers also found that grape color extract inhibited mitosis of rat breast cancer cells in related cell culture tests.

"These studies indicate that components in Concord grape juice can inhibit the growth of certain types of breast cancer cells in rats," explains Keith Singletary, Ph.D., lead author of the study.

In one study, three different concentrations of Concord (purple) grape juice were fed to female Sprague-Dawley rats beginning one week after the administration of a mammary carcinogen. Rats in the control group received the carcinogen and were fed fluids with concentrations of calories, carbohydrates, and organic acids similar to those in the juice concentrations. At the end of the study, mammary tumor mass was reduced by 28 to 36 percent in the groups consuming the two higher juice concentrations compared with mass in control animals. The number of tumors per animal was reduced by 45 to 65 percent in the same two groups of rats that received grape juice.

Concurrent experiments also confirmed that addition of Concord grape color extract to cultures of breast cancer cells derived from carcinogen-induced rat mammary tumors led to a significant, dose-dependent inhibition of mitosis.

"In addition to our own work, other research has suggested that certain components in grapes, possibly the polyphenols, may have an inhibitory or preventive affect on the growth of breast cancer cells," notes Dr. Singletary. "And while these findings are preliminary and based on animal-model research, they certainly suggest the need to look more closely at the possible benefits they may eventually offer women."


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