Among patients with acute kidney injury after cardiac surgery, infusion with the antihypertensive agent fenoldopam, compared with placebo, did not reduce the need for renal replacement therapy (dialysis) or risk of death at 30 days, but was associated with an increased rate of abnormally low blood pressure, according to a study published in JAMA. The study is being posted early online to coincide with its presentation at the European Society of Intensive Care Medicine annual congress.

Decreased renal perfusion may be a major mechanism of acute kidney injury, a common complication after cardiac surgery.  Because of its hemodynamic effects, fenoldopam has been widely promoted for the prevention and therapy of acute kidney injury, with apparent favorable results in cardiac surgery. However, the absence of a definitive trial leaves clinicians uncertain as to whether fenoldopam should be prescribed after cardiac surgery to prevent deterioration in kidney function, according to background information in the article.

Tiziana Bove, M.D., of the IRCCS San Raffaele Scientific Institute, Milan, Italy, and colleagues randomly assigned 667 patients admitted to intensive care units after cardiac surgery with early acute kidney injury to receive fenoldopam infusion (338 patients) or placebo (329 patients). The study was conducted from March 2008 to April 2013 in 19 cardiovascular intensive care units in Italy.

The study was stopped for futility as recommended by the safety committee after a planned interim analysis. Twenty percent of the fenoldopam group required dialysis compared with 18% of the placebo group (p=0.47). In the fenoldopam group, 30-day mortality was 23% vs. 22% in the placebo group (p=0.86). The fenoldopam group had higher rates of hypotension, at 26%, compared with 15% among the placebo group (p=0.001). 

"Given the cost of fenoldopam, the lack of effectiveness, and the increased incidence of hypotension, the use of this agent for renal protection in these patients is not justified," the authors conclude.

This work was supported by a grant from the Italian Ministry of Health. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.