ESCAPE trial shows physical exams as good as imaging and measuring biomarkers for assessing congestive heart failure
Patient history and physical examination, traditionally
the cornerstone diagnostic tool for medical care, may still be among the most
accurate and cost-efficient methods to assess patients with congestive heart failure,
UT Southwestern Medical Center researchers have found.
Such time-honored techniques have diminished in importance
in recent years as doctors have come to rely on high-tech diagnostic approaches,
such as imaging and measuring biomarkers. In the September issue of the American
Heart Association journal, Circulation: Heart Failure, however, UT Southwestern
and other researchers have found that the history and physical exam are still
viable.
"There has been a shift away from the use of the history
and physical examination in patient care," said Dr. Mark Drazner, medical director
of the Heart Failure and Cardiac Transplantation Program at UT Southwestern Medical
Center and the study's lead author. "The key objective of this study was to uncover
whether the history and physical examination remains useful in the modern era."
History and physical examinations were performed for
388 patients enrolled in the Evaluation Study of Congestive Heart Failure and
Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial, and their findings
were recorded on a standardized form. About half of these patients also underwent
an invasive right-heart catheterization to measure how much fluid they had in
their body.
Researchers found that the estimates of the amount of
fluid from the history and physical exam compared favorably to the results of
the invasive measurements: measured right atrial pressure was <8 mm Hg in 82%
of patients with right atrial pressure estimated from jugular veins as <8 mm
Hg, and was >12 mm Hg in 70% of patients when estimated as >12 mm Hg.
Additionally, patients who were estimated to have extra
fluid through the collection of histories and physical exams were found to have
a 50% increased risk of being hospitalized or dying over the next six months.
"Our study touches upon an important clinical question:
If physicians were more adept at performing histories and physicals, would they
rely less on more costly diagnostic tests?" said Dr. Drazner.
"Hopefully, this study might shift the pendulum back
just a bit towards using the history and physical examination in patient care.
It might even get trainees more interested in learning about the history and physical
examination so that this important art can be perpetuated in future generations
of physicians."
The ESCAPE trial was conducted at 26 sites in the U.S.
and Canada.
Scientists from Duke University Medical Center, Ohio
State University Medical Center, Washington Hospital Center, Brigham and Women's
Hospital, the University of Minnesota, Johns Hopkins Hospital and Cleveland Clinic
Foundation also contributed to this study.
The ESCAPE trial was supported by the National Heart,
Lung and Blood Institute and an American Heart Association National Scientist
Development Award.
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