アルコール摂取量はバイパス術後の心臓に関する問題と関連がある（Abstruct # 14440）

バイパス術を受けた男性患者において少量から中等量の飲酒と心血管系合併症が少ないことには関連がある
Light to moderate drinking linked to fewer cardiovascular complications in male bypass patients
冠動脈バイパス術を受けた男性患者のうち少量から中等量（1日2～3杯）の飲酒をする者は非飲酒者と比較し、その後の心臓血管手術、心筋梗塞（MI）、脳卒中および死亡が25%低かった、と2010年American Heart Association学会で発表された。しかし、中等量から大量（1日6杯以上）の飲酒をする左室機能低下を伴うバイパス患者は非飲酒者と比較し、その後の心血管死の確率が倍であった。研究者らは冠動脈バイパス術を施行された患者1,021人に標準的なアンケートを行い、その後3.5年間のバイパス術施行、MI、脳卒中および心血管死に関して調査した。毎日約2杯飲酒する患者は禁酒家と比較し心血管イベントが少なかった。一方、中等量から大量（1日約4杯）の飲酒をする左室機能に問題のある男女は、術後に追加処置を必要としたりMIまたは脳卒中を発現する確率が高かった。少量から中等量のアルコール消費は1日5～30gのアルコールで定義され、中等量から大量は1日60g以上で定義された。
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Light to moderate alcohol consumption (about two to three drinks daily) among male coronary artery bypass patients was associated with 25 percent fewer subsequent cardiovascular procedures, myocardial infarction (MI), strokes and death compared to non-drinkers, in a study presented at the American Heart Association's Scientific Sessions 2010.

However, bypass patients with left ventricular dysfunction who were moderate to heavy drinkers (more than six drinks daily) were twice as likely to have subsequent cardiovascular deaths compared to non-drinkers.

"The benefit of light amounts of alcohol consumption has been documented in healthy individuals, but our analysis showed a benefit from light alcohol intake in post-coronary bypass patients," said Umberto Benedetto, M.D., Ph.D. at the University of Rome La Sapienza in Italy. "However, our analysis indicated that alcohol consumption is not advisable in patients with left ventricular dysfunction and heart failure. No adverse correlation was found between moderate alcohol consumption and any medication."

Light to moderate alcohol consumption was defined as five to 30 grams of alcohol daily; moderate to heavy was defined as more than 60 grams daily.

Researchers used a standard questionnaire to compare alcohol consumption in 1,021 patients who underwent heart bypass and reviewed subsequent bypass procedures, heart attacks, strokes and cardiac deaths during the following 3 1/2 years. Patients consuming about two drinks daily had fewer cardiovascular events when compared to abstainers.
Moreover, moderate to heavy alcohol consumption (about four drinks daily) by patients with left ventricular problems was associated with significantly greater risk of dying.

Results of the study need to be confirmed over a longer follow-up period, with more patients and controls, Benedetto said.

The American Heart Association does not recommend people start consuming alcohol to prevent heart disease because too much alcohol can raise blood pressure and have other negative effects. For those who already drink alcohol, the association recommends women limit themselves to a drink a day and men limit themselves to two drinks per day.

Co-authors are: Giovanni Melina, M.D., Ph.D.; Davide Sansone, M.D.; Roberta Di Bartolomeo, M.D.; Emiliano Angeloni, M.D.; Simone Refice, M.D.; Ivan Stigliano, M.D.; Antonino Roscitano, M.D.; Tommaso Hinna Danesi, M.D.; and Riccardo Sinatra, M.D.