女性において加糖飲料は心血管リスクを上昇させる可能性がある（AHA Abstract # 8438）

MESA：加糖飲料を飲む女性は高中性脂肪血症を発症する傾向にあり2型糖尿病の高リスクである
MESA: Women who drink sugar-sweetened beverages tend to develop high triglycerides and a high risk for type 2 diabetes
1日に2本以上の加糖飲料摂取は女性のウエストラインを拡大させ心血管疾患および糖尿病のリスクを上昇させる可能性があるとの研究結果が2011年American Heart Association学会で発表された。動脈硬化多民族スタディ（Multi-Ethnic Study of Atherosclerosis：MESA）には45～84歳の成人4,166人の食品摂取頻度調査が含まれた。スタディ開始時には心血管疾患を有する者はいなかった。研究者らは2002年から5年間にわたる3つのフォローアップ調査でリスクファクターを評価した。参加者は体重増加、腹囲増加、高密度リポ蛋白（HDLコレステロール）低値、低密度リポ蛋白（LDLコレステロール）高値、高中性脂肪血症、空腹時血糖異常、および2型糖尿病に関して監視された。1日に加糖飲料を2本以上摂取する女性は高中性脂肪血症を発症するリスクが4倍近く高く、腹囲が増加し空腹時血糖異常を発症する確率が有意に高かった。心疾患および脳卒中に対するこれらのリスクファクターは体重増加を来していない女性においても発現した。男性においては同様の関係は認められなかった。
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Drinking two or more sugar-sweetened beverages a day may expand a woman's waistline and increase her risk of heart disease and diabetes, according to research presented at the American Heart Association's Scientific Sessions 2011.

In this study, researchers compared middle-aged and older women who drank two or more sugar-sweetened beverages a day, such as carbonated sodas or flavored waters with added sugar, to women who drank one or less daily. Women consuming two or more beverages per day were nearly four times as likely to develop high triglycerides, and were significantly more likely to increase their waist sizes and to develop impaired fasting glucose levels. The same associations were not observed in men.

"Women who drank more than two sugar-sweetened drinks a day had increasing waist sizes, but weren't necessarily gaining weight," said Christina Shay, Ph.D., lead author of the study and assistant professor at the University of Oklahoma Health Sciences Center in Oklahoma City. "These women also developed high triglycerides and women with normal blood glucose levels more frequently went from having a low risk to a high risk of developing diabetes over time."

The Multi-Ethnic Study of Atherosclerosis (MESA) included food frequency surveys in 4,166 African-American, Caucasian, Chinese-Americans and Hispanic adults 45 to 84 years old. At the beginning of the study the participants didn't have cardiovascular disease.

Researchers assessed risk factors in three follow-up exams spanning five years starting in 2002. Participants were monitored for weight gain, increases in waist circumference, low levels of high-density lipoproteins (HDL cholesterol), high levels of low density lipoproteins (LDL cholesterol), high triglycerides, impaired fasting glucose levels, and type 2 diabetes.

"Most people assume that individuals who consume a lot of sugar-sweetened drinks have an increase in obesity, which in turn, increases their risk for heart disease and diabetes," said Shay, formerly of Northwestern University's Department of Preventive Medicine in Chicago, where the study was conducted. "Although this does occur, this study showed that risk factors for heart disease and stroke developed even when the women didn't gain weight."

Women may have a greater chance for developing cardiovascular disease risk factors from sugar-sweetened drinks because they require fewer calories than men which makes each calorie count more towards cardiovascular risk in women, Shay said.

Researchers have yet to determine exactly how sugar-sweetened beverages influence cardiovascular risk factors such as high triglycerides in individuals who do not gain weight, Shay said, but further work is planned to try and figure that out.

Co-authors include Jennifer A. Nettleton, Ph.D.; Pamela L. Lutsey, Ph.D., M.P.H.; Tamar S. Polonsky, M.D.; Mercedes R. Carnethon, Ph.D.; Cheeling Chan, M.S.; Linda Van Horn, Ph.D., R.D.; and Gregory Burke, M.D.

The National Heart, Lung, and Blood Institute funded the study